Tarık Smanı

(Seville, Spain)

Date of birth: 28/07/1971
Researcher ID: D-5372-2016      Orcid: 0000-0002-1877-7438

PRESENT PROFESIONAL POSITION
Professional Status: Associate Professor of Physiology at the University of Seville.
Center: Faculty of Medicine. Institute of Biomedicine of Sevilla (IBiS).
Department: Medical Physiology and Biophysics, Group of Cardiovascular Pathophysiology.
Address: Avda Manuel Siurot s/n. Hospital Virgen del Rocio. 41013. Sevilla. Spain.
E-mail: tasmani@us.es Tel: +34-955923057

PRESENT RESEARCH AREA
• Molecular and functional calcium signaling in excitable cells: Store operated calcium channels, TRPC and voltage gated Channels.
• Cardiovascular protection from ischemia and reperfusion injuries. Role of urocortin.
• Vascular cell pathophysiology. Vascular tone and smooth muscle proliferation. Role of ion channel in Restenosis.
• microRNA and cardiovascular remodeling.

ACADEMIC AND PROFESSIONAL HONORS
2016- Associate professor; University of Seville (Spain).
2011- 2016 Assistant professor; University of Seville (Spain).
2010-2011 Research associate; Institute of Biomedicine of Seville.
2005-2010 Awardee as Researcher in “Ramon y Cajal” program (Tenure-Track Spanish ministry program).
2001-2005 Research Associate in Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston (USA).
2000 Ph.D. Thesis title: “Homeostasis of calcium in myocytes from pulmonary arterial tree”.
Supervisors: Juan Urena López & José López-Barneo.
1995-2000 PhD Student in Departamento de Fisiologίa Médica y Biofίsica, University of Seville (Spain).
1993 Degree in Biology, Faculté des Sciences, Université de My Ismail, Meknes (Morocco).

PUBLISHED PEER REVIEW JOURNAL ARTICLES
Key: FI: Impact Factor; D = decil, Q = quartil

1. Sanchez-Collado J, Lopez JJ, Jardin I, Camello PJ, Falcon D, Regodon S, Salido GM, Smani T, Rosado JA. (10/9) Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells. Cancers (Basel). 2019 Oct 23;11(11). pii: E1624. doi: 10.3390/cancers11111624. FI: 6,162; Q1.

2. Avila-Medina J, Mayoral-Gonzalez I, Galeano-Otero I, Redondo PC, Rosado JA, Smani T. Pathophysiological Significance of Store-Operated Calcium Entry in Cardiovascular and Skeletal Muscle Disorders and Angiogenesis. Adv Exp Med Biol. 2020;1131:489-504. doi: 10.1007/978-3-030-12457-1_19.

3. Lopez JJ, Jardin I, Albarran L, Sanchez-Collado J, Cantonero C, Salido GM, Smani T, Rosado JA. Molecular Basis and Regulation of Store-Operated Calcium Entry. Adv Exp Med Biol. 2020;1131:445-469. doi: 10.1007/978-3-030-12457-1_17.

4. Lopez E, Frischauf I, Jardin I, Derler I, Muik M, Cantonero C, Salido GM, Smani T, Rosado JA, Redondo PC. (10/8) STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and ICRAC. J Cell Sci. 2019;132(10). pii: jcs226019. doi: 10.1242/jcs.226019. FI: 4,401; Q1

5. Falcon D, Galeano-Otero I, Calderon-Sanchez E, Del Toro R, Martin-Bornez M, Rosado JA, Abdelkrim Hmadcha A, Smani T. TRP channels: Current perspectives in the adverse cardiac remodeling. Front Physiol 2019. ;10:159. doi: 10.3389/fphys.2019.00159. FI: 3,394; Q1.

6. Smani T, Gómez-Gordo L, Regodón S, Woodard GE, Siegfried G, Khatib AM, Rosado JA. TRP channels in angiogenesis and other endothelial functions. Front Physiol 2018; 9:1731. doi: 10.3389/fphys.2018.01731. FI: 3,394; Q1.

7. Albarran A, Lopez JJ, Jardin I, Berna-Erro A, Smani T, Camello PJ, Salido GM, Rosado JA. EFHB is a novel cytosolic Ca2+ sensor that modulates STIM1-SARAF interaction. Cell Physiol Biochem 2018;51(3):1164-1178. FI: 5,5; D1.

8. Jardin I, Diez-Bello R, Lopez JJ, Redondo PC, Salido GM, Smani T, Rosado JA. TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface expression. Cancers 2018;10(9), pii: E331. FI: 5,326; Q1.

9. Domínguez-Rodríguez A, Mayoral-Gonzalez I, Avila-Medina J, de Rojas-de Pedro ES, Calderón-Sánchez E, Díaz I, Hmadcha A, Castellano A, Rosado JA, Benitah J-P, Gomez AM, Ordoñez A and Smani, Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion. Front. Physiol. 2018; 9:813. doi: 10.3389/fphys.2018.00813. FI: 3,394; Q1.

10. López-Beas J, Capilla-González V, Aguilera Y, Mellado N, Lachaud CC, Martín F, Smani T, Soria B, Hmadcha A. miR-7 modulates human embryonic stem cell differentiation into insulin-producing beta-like cells and contributes to cell maturation. Mol Ther Nucleic Acids. 2018: 12:463-477. https://doi.org/10.1016/j.omtn.2018.06.002. Aceptado. FI: 6,39; D1.